Peptide Information

General Information of This Peptide
Peptide ID
BTDP008724
Peptide Name
Cysteine-rich venom protein helothermine
Species
Heloderma horridum horridum (Mexican beaded lizard)
Uniprot Name
CRVP_HELHO
Alphafold ID
Q91055
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q91055
Sequence
MILLSLYLCLAAMLHQSEGEASPKLPGLMTSNPDQQTEITDKHNNLRRIVEPTASNMLKM
TWSNKIAQNAQRSANQCTLEHTSKEERTIDGVECGENLFFSSAPYTWSYAIQNWFDERKY
FRFNYGPTAQNVMIGHYTQVVWYRSYELGCAIAYCPDQPTYKYYQVCQYCPGGNIRSRKY
TPYSIGPPCGDCPDACDNGLCTNPCKQNDVYNNCPDLKKQVGCGHPIMKDCMATCKCLTE
IK
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Sequence Length
242
Mass (Da)
27493
Sequence Removed Signal Peptide
EASPKLPGLMTSNPDQQTEITDKHNNLRRIVEPTASNMLKMTWSNKIAQNAQRSANQCTL
EHTSKEERTIDGVECGENLFFSSAPYTWSYAIQNWFDERKYFRFNYGPTAQNVMIGHYTQ
VVWYRSYELGCAIAYCPDQPTYKYYQVCQYCPGGNIRSRKYTPYSIGPPCGDCPDACDNG
LCTNPCKQNDVYNNCPDLKKQVGCGHPIMKDCMATCKCLTEIK
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Disulfide Bond
77-155;94-170;150-167;189-196;192-201;205-237;214-231;223-235
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Helodermatidae
Genus: Heloderma
Species: Heloderma horridum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv . . . . [1], [2], [3], [4]
References
Ref 1 Primary structure and properties of helothermine, a peptide toxin that blocks ryanodine receptors. Biophys J. 1995 Jun;68(6):2280-8. doi: 10.1016/S0006-3495(95)80410-8.
Ref 2 Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom. Toxicon. 1990;28(3):299-309. doi: 10.1016/0041-0101(90)90065-f.
Ref 3 The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells. J Membr Biol. 1994 Apr;139(1):49-55. doi: 10.1007/BF00232674.
Ref 4 Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules. Exp Brain Res. 1996 Jun;110(1):15-20. doi: 10.1007/BF00241369.
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