Peptide Information

General Information of This Peptide
Peptide ID
BTDP008678
Peptide Name
Omega-theraphotoxin-Gr1a
Symonym
Omega-grammotoxin SIA
Species
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Uniprot Name
WGRTX_GRARO
Alphafold ID
P60590
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1KOZ
Sequence
MKAQIFVVVLGLAALSVLCYGSEADESALHEEIFQLLAASDEVPKPQERDCVRFWGKCSQ
TSDCCPHLACKSKWPRNICVWDGSVGK
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Sequence Length
87
Mass (Da)
9601
Sequence Removed Signal Peptide
DCVRFWGKCSQTSDCCPHLACKSKWPRNICVWDGSV
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Disulfide Bond
51-65;58-70;64-79
PDB ID
1KOZ
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola rosea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
19 μM
 .
Modifier
 [1- 7]
References
Ref 1 Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 2011 Sep 1;58(3):265-76. doi: 10.1016/j.toxicon.2011.06.006. Epub 2011 Jun 28.
Ref 2 Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses. Mol Pharmacol. 1993 Aug;44(2):451-60.
Ref 3 Complete and reversible block by omega-grammotoxin SIA of glutamatergic synaptic transmission between cultured rat hippocampal neurons. Neurosci Lett. 1995 Dec 8;201(2):135-8. doi: 10.1016/0304-3940(95)12169-2.
Ref 4 Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA. Mol Pharmacol. 1997 Dec;52(6):1095-104. doi: 10.1124/mol.52.6.1095.
Ref 5 Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8585-9. doi: 10.1073/pnas.95.15.8585.
Ref 6 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
Ref 7 Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel. J Mol Biol. 2002 Aug 16;321(3):517-26. doi: 10.1016/s0022-2836(02)00595-8.
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