Peptide Information

General Information of This Peptide
Peptide ID
BTDP008663
Peptide Name
Scorpine
Symonym
Panscorpine
Species
Pandinus imperator (Emperor scorpion)
Uniprot Name
KBX3_PANIM
Alphafold ID
P56972
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 7M1D
Sequence
MNSKLTALIFLGLIAIAYCGWINEEKIQKKIDERMGNTVLGGMAKAIVHKMAKNEFQCMA
NMDMLGNCEKHCQTSGEKGYCHGTKCKCGTPLSY
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Sequence Length
94
Mass (Da)
10394
Signal Sequence
MNSKLTALIFLGLIAIAYC
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Sequence Removed Signal Peptide
GWINEEKIQKKIDERMGNTVLGGMAKAIVHKMAKNEFQCMANMDMLGNCEKHCQTSGEKG
YCHGTKCKCGTPLSY
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Disulfide Bond
58-81;68-86;72-88
PDB ID
7M1D , 7M1E
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Pandinus
Species: Pandinus imperator
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv7.1 Inhibition rate
20 %
18 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
36 %
18 μM
Blocker
 [1]
References
Ref 1 Structural and functional studies of scorpine: A channel blocker and cytolytic peptide. Toxicon. 2023 Jan 15;222:106985. doi: 10.1016/j.toxicon.2022.106985. Epub 2022 Nov 24.
Ref 2 Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom. FEBS Lett. 2000 Apr 14;471(2-3):165-8. doi: 10.1016/s0014-5793(00)01384-3.
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