Peptide Information

General Information of This Peptide
Peptide ID
BTDP008634
Peptide Name
Kunitz-type serine protease inhibitor BmKTT-2
Symonym
Delta-KTx 3.1
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
VKT31_MESMA
Alphafold ID
P0DJ50
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJ50
Sequence
MMNVITVVGIILSVVCTISDAEGVDCTLPSDTGRCKAYFIRYFYNQKAGECQKFVYGGCE
GNSNNFLTKSDCCKQCSPGKC
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Sequence Length
81
Mass (Da)
8825
Sequence Removed Signal Peptide
EGVDCTLPSDTGRCKAYFIRYFYNQKAGECQKFVYGGCEGNSNNFLTKSDCCKQCSPGKC
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Disulfide Bond
26-76;35-59;51-72;73-81
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Dissociation constant
420 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
371.3 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
371.3 nM
 .
Blocker
 [1], [2]
References
Ref 1 Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. PLoS One. 2013;8(4):e60201. doi: 10.1371/journal.pone.0060201. Epub 2013 Apr 3.
Ref 2 Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem. 2012 Apr 20;287(17):13813-21. doi: 10.1074/jbc.M112.343996. Epub 2012 Feb 21.
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