Peptide Information

General Information of This Peptide
Peptide ID
BTDP008630
Peptide Name
Neurotoxin beta-KTx 14.3
Species
Lychas mucronatus (Chinese swimming scorpion)
Uniprot Name
KBX23_LYCMC
Alphafold ID
P0CI42
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 7LGV
Sequence
MKQYIFFLALIVLTATFAEAGKKTEILDKVKKVFSKGIAGVADLNNMSELGCPFIEKWCE
DHCESKKQVGKCENFDCSCVKLGGK
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Sequence Length
85
Mass (Da)
9425
Signal Sequence
MKQYIFFLALIVLTATFAEA
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Sequence Removed Signal Peptide
GKKTEILDKVKKVFSKGIAGVADLNNMSELGCPFIEKWCEDHCESKKQVGKCENFDCSCV
KLGGK
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Disulfide Bond
52-72;59-77;63-79
PDB ID
7LGV
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Lychas
Species: Lychas mucronatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-IR Inhibition rate .
22 μM
Blocker
 [2]
 Target Info    Kv7.1 IC50
22 μM
 .
Blocker
 [2]
References
Ref 1 Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 2010 Jul 28;11:452. doi: 10.1186/1471-2164-11-452.
Ref 2 Beta-KTx14.3, a scorpion toxin, blocks the human potassium channel KCNQ1. Biochim Biophys Acta Proteins Proteom. 2023 Jul 1;1871(4):140906. doi: 10.1016/j.bbapap.2023.140906. Epub 2023 Mar 12.
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