Peptide Information

General Information of This Peptide
Peptide ID
BTDP008629
Peptide Name
Mu-theraphotoxin-Cg2a 3
Symonym
Jingzhaotoxin-IV; Peptide F1-23.73
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZ31C_CHIGU
Alphafold ID
P0CH56
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0CH56
Sequence
MKVSVVITLAVLGVMFVWASAAELKERGSDQRDSPAWIKSMERIFQSEERECTKFLGGCS
EDSECCPHLGCKDVLYYCAWDGTFGK
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Sequence Length
86
Mass (Da)
9632
Sequence Removed Signal Peptide
ECTKFLGGCSEDSECCPHLGCKDVLYYCAWDGTF
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Disulfide Bond
52-66;59-71;65-78
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11 Inhibition rate
9 %
100 μM
Blocker
 [1]
References
Ref 1 Effects and mechanism of gating modifier spider toxins on the hERG channel. Toxicon. 2021 Jan 15;189:56-64. doi: 10.1016/j.toxicon.2020.11.008. Epub 2020 Nov 17.
Ref 2 JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao. Toxicon. 2008 Dec 15;52(8):871-80. doi: 10.1016/j.toxicon.2008.08.018. Epub 2008 Sep 24.
Ref 3 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
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