Peptide Information

General Information of This Peptide
Peptide ID
BTDP008623
Peptide Name
Potassium channel toxin gamma-KTx 1.8
Symonym
CeErgTx5
Species
Centruroides elegans (Bark scorpion)
Uniprot Name
KGX18_CENEL
Alphafold ID
P0C893
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C893
Sequence
DRDSCIDKSRCSKYGYYQECQDCCKKAGHNGGTCMFFKCKCA
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Sequence Length
42
Mass (Da)
4782
Sequence Removed Signal Peptide
DRDSCIDKSRCSKYGYYQECQDCCKKAGHNGGTCMFFKCKCA
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Disulfide Bond
5-23;11-34;20-39;24-41
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides elegans
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11.2 Inhibition rate .
200 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate
90 %
200 nM
Blocker
 [1]
 Target Info    Kv11.3 Inhibition rate
100 %
200 nM
Blocker
 [1]
References
Ref 1 Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans. Neurochem Res. 2008 Aug;33(8):1525-33. doi: 10.1007/s11064-008-9634-8. Epub 2008 Mar 13.
Ref 2 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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