Peptide Information

General Information of This Peptide
Peptide ID
BTDP008585
Peptide Name
Potassium channel toxin alpha-KTx 6 hetlaxin
Species
Heterometrus laoticus (Thai giant scorpion)
Uniprot Name
KAX6V_HETLA
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
ISCTGSKQCYDPCKKKTGCPNAKCMNKSCXCYGC
   Click to Show/Hide
Sequence Length
34
Mass (Da)
3666
Sequence Removed Signal Peptide
ISCTGSKQCYDPCKKKTGCPNAKCMNKSCXCYGC
   Click to Show/Hide
Disulfide Bond
3-24;9-29;13-31;19-34
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus laoticus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KcsA-Kv1.3 IC50
480 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
0.48 μM
 .
Blocker
 [1], [2]
 Target Info    KcsA-Kv1.1 IC50
6.7 μM
 .
Blocker
 [1], [2]
 Target Info    Kv1.1 IC50
6.7 μM
 .
Blocker
 [1], [2]
References
Ref 1 Vietnamese Heterometrus laoticus scorpion venom: evidence for analgesic and anti-inflammatory activity and isolation of new polypeptide toxin acting on Kv1.3 potassium channel. Toxicon. 2014 Jan;77:40-8. doi: 10.1016/j.toxicon.2013.10.027. Epub 2013 Nov 1.
Ref 2 Hetlaxin, a new toxin from the Heterometrus laoticus scorpion venom, interacts with voltage-gated potassium channel Kv1.3. Dokl Biochem Biophys. 2013 Mar-Apr;449:109-11. doi: 10.1134/S1607672913020142. Epub 2013 May 9.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.