Peptide Information

General Information of This Peptide
Peptide ID
BTDP008578
Peptide Name
U20-theraphotoxin-Cg1a 1
Symonym
Jingzhaotoxin-35; Peptide F3-18.97
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZ35A_CHIGU
Alphafold ID
B1P1F9
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B1P1F9
Sequence
MKVSVLITLAVLGVMFVWTSAAELEERGSDQPAWLKSLERIFQSEERDCRALYGGCTKDE
DCCKHLACRRTLPTYCAWDLTFP
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Sequence Length
83
Mass (Da)
9461
Sequence Removed Signal Peptide
DCRALYGGCTKDEDCCKHLACRRTLPTYCAWDLTFP
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Disulfide Bond
49-63;56-68;62-76
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11 Inhibition rate
15 %
100 μM
Blocker
 [3]
 Target Info    Kv2.1 IC50
3.62 μM
 .
Blocker
 [4]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Effects and mechanism of gating modifier spider toxins on the hERG channel. Toxicon. 2021 Jan 15;189:56-64. doi: 10.1016/j.toxicon.2020.11.008. Epub 2020 Nov 17.
Ref 4 Jingzhaotoxin-35, a novel gating-modifier toxin targeting both Nav1.5 and Kv2.1 channels. Toxicon. 2014 Dec 15;92:90-6. doi: 10.1016/j.toxicon.2014.10.008. Epub 2014 Oct 15.
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