Peptide Information

General Information of This Peptide
Peptide ID
BTDP008557
Peptide Name
Tityustoxin-19
Symonym
Potassium channel toxin beta-Ktx 2
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KBX2_TITSE
Alphafold ID
P86822
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P86822
Sequence
MVATNRCCVFALLFALLLVHSLTEAGKGKEILGKIKEKIIEAKDKMKAGWERLTSQSEYA
CPAIDKFCEDHCAAKKAVGKCDDFKCNCIKL
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Sequence Length
91
Mass (Da)
10083
Signal Sequence
MVATNRCCVFALLFALLLVHSLTEA
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Sequence Removed Signal Peptide
GKGKEILGKIKEKIIEAKDKMKAGWERLTSQSEYACPAIDKFCEDHCAAKKAVGKCDDFK
CNCIKL
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Disulfide Bond
61-81;68-86;72-88
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 IC50
544 nM
 .
Ts19 fragment II
 [1], [2], [3], [4]
References
Ref 1 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 2 Isolation and characterization of Ts19 Fragment II, a new long-chain potassium channel toxin from Tityus serrulatus venom. Peptides. 2016 Jun;80:9-17. doi: 10.1016/j.peptides.2015.06.004. Epub 2015 Jun 25.
Ref 3 Tityus serrulatus venom peptidomics: assessing venom peptide diversity. Toxicon. 2008 Oct;52(5):611-8. doi: 10.1016/j.toxicon.2008.07.010. Epub 2008 Jul 31.
Ref 4 Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity. Toxicon. 2014 Nov;90:326-36. doi: 10.1016/j.toxicon.2014.08.064. Epub 2014 Sep 6.
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