Peptide Information

General Information of This Peptide
Peptide ID
BTDP008556
Peptide Name
Thrombin-like enzyme gyroxin B1.3
Symonym
Fibrinogen-clotting enzyme; Snake venom serine protease
Species
Crotalus durissus terrificus (South American rattlesnake)
Uniprot Name
VSP13_CRODU
Alphafold ID
B0FXM1
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: B0FXM1
Sequence
MVLIRVLANLLILQLSYAQKSSELVIGGDECNINEHNFLVALYEYWSQSFLCGGTLINGE
WVLTAAHCDRKHILIYVGVHDRSVQFDKEQRRFPKEKYFFNCRNNFTKWDKDIMLIRLNK
PVSYSEHIAPLSLPSSPPIVGSVCRVMGWGTIKSPQETLPDVPHCANINLLDYEVCRTAH
PQFRLPATSRILCAGVLEGGIDTCHRDSGGPLICNGEFQGIVSWGDGPCAQPDKPALYSK
VFDHLDWIQNIIAGSETVNCPS
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Sequence Length
262
Mass (Da)
29347
Signal Sequence
MVLIRVLANLVILQLSYA
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Sequence Removed Signal Peptide
QKSSELVIGGDECNINEHNFLVALYEYWSQSFLCGGTLINGEWVLTAAHCDRKHILIYVG
VHDRSVQFDKEQRRFPKEKYFFNCRNNFTKWDKDIMLIRLNKPVSYSEHIAPLSLPSSPP
IVGSVCRVMGWGTIKSPQETLPDVPHCANINLLDYEVCRTAHPQFRLPATSRILCAGVLE
GGIDTCHRDSGGPLICNGEFQGIVSWGDGPCAQPDKPALYSKVFDHLDWIQNIIAGSETV
NCPS
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Disulfide Bond
31-165;52-68;102-260;144-214;176-193;204-229
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Crotalus
Species: Crotalus durissus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv10 Inhibition rate
58 %
5 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10 Inhibition rate
58 %
5 μM
Blocker
 [4]
References
Ref 1 Cloning of serine protease cDNAs from Crotalus durissus terrificus venom gland and expression of a functional Gyroxin homologue in COS-7 cells. Toxicon. 2009 Aug;54(2):110-20. doi: 10.1016/j.toxicon.2009.03.022. Epub 2009 Mar 31.
Ref 2 Gyroxin fails to modify in vitro release of labelled dopamine and acetylcholine from rat and mouse striatal tissue. Toxicon. 2001 Jun;39(6):843-53. doi: 10.1016/s0041-0101(00)00222-1.
Ref 3 Gyroxin increases blood-brain barrier permeability to Evans blue dye in mice. Toxicon. 2011 Jan;57(1):162-7. doi: 10.1016/j.toxicon.2010.06.027. Epub 2010 Jul 14.
Ref 4 Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. Sci Rep. 2020 Mar 11;10(1):4476. doi: 10.1038/s41598-020-61258-x.
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