Peptide Information

General Information of This Peptide
Peptide ID
BTDP008551
Peptide Name
R.appendiculatus Kunitz/BPTI-like protein
Symonym
Kunitz/BPTI-like protein; Pancreatic trypsin inhibitor
Species
Rhipicephalus appendiculatus (Brown ear tick)
Uniprot Name
TICK1_RHIAP
Alphafold ID
C5H8E7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2W8X
Sequence
MASTLKLFMLLPVILLLLQEAYGTIDVEARGDNFNCNKREGPCSQRSLCECDPNLQLGRH
SDQLWHYNLRTNRCERGGYRDNCNSHTSSGACVMACER
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Sequence Length
98
Mass (Da)
11111
Signal Sequence
MASTLKLFMLLPVILLLLQEAYG
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Sequence Removed Signal Peptide
TIDVEARGDNFNCNKREGPCSQRSLCECDPNLQLGRHSDQLWHYNLRTNRCERGGYRDNC
NSHTSSGACVMACER
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Disulfide Bond
36-51;43-83;49-96;74-92
PDB ID
2W8X
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Ixodida
Family: Ixodidae
Genus: Rhipicephalus
Species: Rhipicephalus appendiculatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 IC50
1 μM
 .
Activator
 [1], [2]
References
Ref 1 An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure. J Mol Biol. 2009 Jun 19;389(4):734-47. doi: 10.1016/j.jmb.2009.04.045. Epub 2009 Apr 24.
Ref 2 De novo assembly and annotation of the salivary gland transcriptome of Rhipicephalus appendiculatus male and female ticks during blood feeding. Ticks Tick Borne Dis. 2016 Jun;7(4):536-48. doi: 10.1016/j.ttbdis.2016.01.014. Epub 2016 Jan 22.
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