Peptide Information

General Information of This Peptide
Peptide ID
BTDP008537
Peptide Name
Potassium channel toxin gamma-KTx 2.2
Symonym
BmKK7; BmKKx2
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KGX22_MESMA
Alphafold ID
P59938
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6AU7
Sequence
MKISFVLLLTLFICSIGWSEARPTDIKCSASYQCFPVCKSRFGKTNGRCVNGLCDCF
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Sequence Length
57
Mass (Da)
6360
Signal Sequence
MKISFVLLLTLFICSIGWSEA
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Sequence Removed Signal Peptide
RPTDIKCSASYQCFPVCKSRFGKTNGRCVNGLCDCF
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Disulfide Bond
28-49;34-54;38-56
PDB ID
6AU7 , 6AUP
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11 IC50
6.7 nM
 .
Blocker
 [5]
References
Ref 1 Molecular dissection of venom from Chinese scorpion Mesobuthus martensii: identification and characterization of four novel disulfide-bridged venom peptides. Peptides. 2006 Jul;27(7):1745-54. doi: 10.1016/j.peptides.2006.01.012. Epub 2006 Mar 2.
Ref 2 Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. PLoS One. 2013;8(4):e60201. doi: 10.1371/journal.pone.0060201. Epub 2013 Apr 3.
Ref 3 Short-chain peptides identification of scorpion Buthus martensi Karsch venom by employing high orthogonal 2D-HPLC system and tandem mass spectrometry. Proteomics. 2012 Oct;12(19-20):3076-84. doi: 10.1002/pmic.201200224. Epub 2012 Sep 19.
Ref 4 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
Ref 5 hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. PLoS One. 2013 Dec 26;8(12):e84903. doi: 10.1371/journal.pone.0084903. eCollection 2013.
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