Peptide Information

General Information of This Peptide
Peptide ID
BTDP008516
Peptide Name
Potassium channel toxin alpha-KTx 8.1
Symonym
AmP01
Species
Androctonus mauritanicus mauritanicus (Scorpion)
Uniprot Name
KAX81_ANDMA
Alphafold ID
P56215
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1ACW
Sequence
VSCEDCPEHCSTQKAQAKCDNDKCVCEPI
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Sequence Length
29
Mass (Da)
3185
Sequence Removed Signal Peptide
VSCEDCPEHCSTQKAQAKCDNDKCVCEPI
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Disulfide Bond
3-19;6-24;10-26
PDB ID
1ACW
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus mauritanicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2 Dissociation constant
100 nM
 .
Blocker
 [1], [2]
 Target Info    KCa2.2 Dissociation constant
>1 μM
 .
Blocker
 [1], [2], [3]
 Target Info    KCa2.3 Dissociation constant
>1 μM
 .
Blocker
 [1], [2], [3]
 Target Info    KCa2.2 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [2]
References
Ref 1 Characterization of PO1, a new peptide ligand of the apamin-sensitive Ca2+ activated K+ channel. Int J Pept Protein Res. 1996 Dec;48(6):514-21. doi: 10.1111/j.1399-3011.1996.tb00870.x.
Ref 2 Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29.
Ref 3 Solution structure of P01, a natural scorpion peptide structurally analogous to scorpion toxins specific for apamin-sensitive potassium channel. Proteins. 1996 Mar;24(3):359-69. doi: 10.1002/(SICI)1097-0134(199603)24:3<359::AID-PROT9>3.0.CO;2-B.
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