Peptide Information

General Information of This Peptide
Peptide ID
BTDP008509
Peptide Name
Potassium channel toxin alpha-KTx 5.3
Symonym
Neurotoxin BmP05; Potassium ion channel blocker P05
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KAX53_MESMA
Alphafold ID
Q9TVX3
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q9TVX3
Sequence
MHNYYKIVLIMVAFFAVIITFSNIQVEGAVCNLKRCQLSCRSLGLLGKCIGDKCECVKHG
K
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Sequence Length
61
Mass (Da)
6808
Signal Sequence
MHNYYKIVLIMVAFFAVIITFSNIQVEG
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Sequence Removed Signal Peptide
AVCNLKRCQLSCRSLGLLGKCIGDKCECVKHGK
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Disulfide Bond
31-49;36-54;40-56
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.3 IC50
3.76 nM
 .
Blocker
 [5]
 Target Info    KCa2 IC50
920 nM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Genomic organization of three neurotoxins active on small conductance Ca2+-activated potassium channels from the scorpion Buthus martensi Karsch. FEBS Lett. 1999 Jun 11;452(3):360-4. doi: 10.1016/s0014-5793(99)00651-1.
Ref 2 Characterization of four toxins from Buthus martensi scorpion venom, which act on apamin-sensitive Ca2+-activated K+ channels. Eur J Biochem. 1997 Apr 15;245(2):457-64. doi: 10.1111/j.1432-1033.1997.00457.x.
Ref 3 Gene expression, mutation, and structure-function relationship of scorpion toxin BmP05 active on SK(Ca) channels. Biochemistry. 2002 Feb 26;41(8):2844-9. doi: 10.1021/bi011367z.
Ref 4 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
Ref 5 Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013 May 3;288(18):12544-53. doi: 10.1074/jbc.M112.433888. Epub 2013 Mar 19.
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