Peptide Information

General Information of This Peptide
Peptide ID
BTDP008508
Peptide Name
Potassium channel toxin alpha-KTx 5.2
Symonym
AmPO5; Leiurotoxin I-like toxin P05
Species
Androctonus mauritanicus mauritanicus (Scorpion)
Uniprot Name
KAX52_ANDMA
Alphafold ID
P31719
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1PNH
Sequence
TVCNLRRCQLSCRSLGLLGKCIGVKCECVKH
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Sequence Length
31
Mass (Da)
3421
Sequence Removed Signal Peptide
TVCNLRRCQLSCRSLGLLGKCIGVKCECVKH
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Disulfide Bond
3-21;8-26;12-28
PDB ID
1PNH
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus mauritanicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2.2 Dissociation constant
22 nM
 .
Blocker
 [1]
 Target Info    KCa2.2 Dissociation constant
22 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    KCa2.3 Dissociation constant
25 nM
 .
Blocker
 [1]
 Target Info    KCa2.3 Dissociation constant
25 nM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29.
Ref 2 Characterization of a new leiurotoxin I-like scorpion toxin. PO5 from Androctonus mauretanicus mauretanicus. FEBS Lett. 1993 Apr 12;320(3):189-92. doi: 10.1016/0014-5793(93)80583-g.
Ref 3 P05, a new leiurotoxin I-like scorpion toxin: synthesis and structure-activity relationships of the alpha-amidated analog, a ligand of Ca(2+)-activated K+ channels with increased affinity. Biochemistry. 1993 Mar 23;32(11):2763-70. doi: 10.1021/bi00062a005.
Ref 4 Solution structure of P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive potassium channel. Biochemistry. 1993 Nov 16;32(45):11969-76. doi: 10.1021/bi00096a005.
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