Peptide Information

General Information of This Peptide
Peptide ID
BTDP008507
Peptide Name
Potassium channel toxin alpha-KTx 5.1
Symonym
Leiurotoxin I; Leiurotoxin-1; Scyllatoxin
Species
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Uniprot Name
KAX51_LEIHE
Alphafold ID
P16341
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1SCY
Sequence
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
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Sequence Length
31
Mass (Da)
3430
Sequence Removed Signal Peptide
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
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Disulfide Bond
3-21;8-26;12-28
PDB ID
1SCY
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Leiurus
Species: Leiurus quinquestriatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2.2 Dissociation constant
0.2 nM
 .
Blocker
 [1]
 Target Info    KCa2.2 Dissociation constant
0.2 nM
 .
Blocker
 [1- 6]
 Target Info    KCa2.3 Dissociation constant
1.1 nM
 .
Blocker
 [1]
 Target Info    KCa2.3 Dissociation constant
1.1 nM
 .
Blocker
 [1- 6]
 Target Info    KCa2.2 Dissociation constant
3.8 nM
 .
Blocker
 [1- 6]
 Target Info    KCa2.1 Dissociation constant
325 nM
 .
Blocker
 [1- 6]
 Target Info    KCa2.1 Dissociation constant
325 nM
 .
Blocker
 [1]
 Target Info    KCa2.3 Dissociation constant
2.5 μM
 .
Blocker
 [1- 6]
References
Ref 1 Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29.
Ref 2 Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom. J Biol Chem. 1988 Jul 25;263(21):10192-7.
Ref 3 Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization. J Biol Chem. 1990 Mar 15;265(8):4753-9.
Ref 4 Role of disulfide bonds in folding and activity of leiurotoxin I: just two disulfides suffice. Biochemistry. 2002 Sep 24;41(38):11488-94. doi: 10.1021/bi026136m.
Ref 5 Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones). Toxicon. 2006 May;47(6):628-39. doi: 10.1016/j.toxicon.2006.01.015. Epub 2006 Mar 23.
Ref 6 Solution conformation of leiurotoxin I (scyllatoxin) by 1H nuclear magnetic resonance. Resonance assignment and secondary structure. FEBS Lett. 1990 Jan 29;260(2):249-53. doi: 10.1016/0014-5793(90)80115-y.
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