Peptide Information

General Information of This Peptide
Peptide ID
BTDP008501
Peptide Name
Potassium channel toxin alpha-KTx 4.2
Symonym
Neurotoxin Ts-kappa; Tityustoxin-9
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KAX42_TITSE
Alphafold ID
P56219
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1TSK
Sequence
MKVLYGILIIFILCSMFYLSQEVVIGQRCYRSPDCYSACKKLVGKATGKCTNGRCDC
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Sequence Length
57
Mass (Da)
6392
Signal Sequence
MKVLYGILIIFILCSMFYLSQEVVIG
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Sequence Removed Signal Peptide
QRCYRSPDCYSACKKLVGKATGKCTNGRCDC
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Disulfide Bond
29-50;35-55;39-57
PDB ID
1TSK , 6ATL
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2.2 Dissociation constant
80 nM
 .
Blocker
 [1- 7]
 Target Info    KCa2.2 Dissociation constant
80 nM
 .
Blocker
 [3]
 Target Info    KCa2.3 Dissociation constant
197 nM
 .
Blocker
 [1- 7]
 Target Info    KCa2.3 Dissociation constant
197 nM
 .
Blocker
 [3]
 Target Info    Kv11 Inhibition rate
53 %
5 μM
Blocker
 [4]
 Target Info    ERG1 Inhibition rate
53 %
5 μM
Blocker
 [1- 7]
References
Ref 1 Characterization of a new peptide from Tityus serrulatus scorpion venom which is a ligand of the apamin-binding site. FEBS Lett. 1996 Jul 15;390(1):81-4. doi: 10.1016/0014-5793(96)00616-3.
Ref 2 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 3 Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29.
Ref 4 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 5 Tityus serrulatus scorpion venom and toxins: an overview. Protein Pept Lett. 2009;16(8):920-32. doi: 10.2174/092986609788923329.
Ref 6 Solution structure of TsKapa, a charybdotoxin-like scorpion toxin from Tityus serrulatus with high affinity for apamin-sensitive Ca(2+)-activated K+ channels. Proteins. 1997 Nov;29(3):359-69. doi: 10.1002/(sici)1097-0134(199711)29:3<359::aid-prot9>3.0.co;2-5.
Ref 7 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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