Peptide Information

General Information of This Peptide
Peptide ID
BTDP008492
Peptide Name
Potassium channel toxin alpha-KTx 26.1
Symonym
Neurotoxin BmK86
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA261_MESMA
Alphafold ID
A7KJJ7
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: A7KJJ7
Sequence
MSRLFVFILIALFLSAIIDVMSNFKVEGACSKPCRKYCIDKGARNGKCINGRCHCYY
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Sequence Length
57
Mass (Da)
6469
Sequence Removed Signal Peptide
MSRLFVFILIALFLSAIIDVMSNFKVEGACSKPCRKYCIDKGARNGKCINGRCHCYY
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Disulfide Bond
30-48;34-53;38-55
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
150 nM
 . . [1], [2]
 Target Info    Kv1.3 IC50
150 nM
 .
Blocker
 [1]
References
Ref 1 Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun. 2007 Sep 7;360(4):728-34. doi: 10.1016/j.bbrc.2007.06.108. Epub 2007 Jul 2.
Ref 2 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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