Peptide Information

General Information of This Peptide
Peptide ID
BTDP008485
Peptide Name
Potassium channel toxin alpha-KTx 2.5
Symonym
Hongotoxin-1
Species
Centruroides limbatus (Bark scorpion)
Uniprot Name
KAX25_CENLM
Alphafold ID
P59847
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1HLY
Sequence
TVIDVKCTSPKQCLPPCKAQFGIRAGAKCMNGKCKCYPH
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Sequence Length
39
Mass (Da)
4226
Sequence Removed Signal Peptide
TVIDVKCTSPKQCLPPCKAQFGIRAGAKCMNGKCKCYPH
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Disulfide Bond
7-29;13-34;17-36
PDB ID
1HLY
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides limbatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 IC50
0.031 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.3 IC50
0.086 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.2 IC50
0.17 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.6 IC50
6 nM
 .
Blocker
 [1], [2], [3]
References
Ref 1 Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem. 1998 Jan 30;273(5):2639-44. doi: 10.1074/jbc.273.5.2639.
Ref 2 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 3 Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels. Bioconjug Chem. 2002 May-Jun;13(3):416-25. doi: 10.1021/bc015543s.
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