Peptide Information

General Information of This Peptide
Peptide ID
BTDP008463
Peptide Name
Potassium channel toxin alpha-KTx 14.2
Symonym
BmKK2; BmTXKS3; KK1; Neurotoxin BmP07; Potassium ion channel blocker P07; Toxin Kk2
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA142_MESMA
Alphafold ID
Q95NK7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1PVZ
Sequence
MKIFFAILLILAVCSMAIWTVNGTPFAIKCATDADCSRKCPGNPPCRNGFCACT
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Sequence Length
54
Mass (Da)
5786
Signal Sequence
MKIFFAILLILAVCSMAIWTVNG
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Sequence Removed Signal Peptide
TPFAIKCATDADCSRKCPGNPPCRNGFCACT
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Disulfide Bond
30-46;36-51;40-53
PDB ID
1PVZ
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Blocker
 [1- 5]
References
Ref 1 Molecular cloning and characterization of four scorpion K(+)-toxin-like peptides: a new subfamily of venom peptides (alpha-KTx14) and genomic analysis of a member. Biochimie. 2001 Sep;83(9):883-9. doi: 10.1016/s0300-9084(01)01326-8.
Ref 2 Precursors of three unique cysteine-rich peptides from the scorpion Buthus martensii Karsch. Comp Biochem Physiol B Biochem Mol Biol. 2002 Apr;131(4):749-56. doi: 10.1016/s1096-4959(02)00020-9.
Ref 3 Purification and pharmacological characterization of BmKK2 (alpha-KTx 14.2), a novel potassium channel-blocking peptide, from the venom of Asian scorpion Buthus martensi Karsch. Toxicon. 2004 Jun 15;43(8):895-900. doi: 10.1016/j.toxicon.2003.11.028.
Ref 4 Short-chain peptides identification of scorpion Buthus martensi Karsch venom by employing high orthogonal 2D-HPLC system and tandem mass spectrometry. Proteomics. 2012 Oct;12(19-20):3076-84. doi: 10.1002/pmic.201200224. Epub 2012 Sep 19.
Ref 5 Solution structure of BmKK2, a new potassium channel blocker from the venom of chinese scorpion Buthus martensi Karsch. Proteins. 2004 Jun 1;55(4):835-45. doi: 10.1002/prot.20117.
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