Peptide Information

General Information of This Peptide
Peptide ID
BTDP008460
Peptide Name
Potassium channel toxin alpha-KTx 13.1
Symonym
Toxin Tc1; Toxin To1
Species
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Uniprot Name
KA131_TITOB
Alphafold ID
P83243
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1JLZ
Sequence
ACGSCRKKCKGSGKCINGRCKCY
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Sequence Length
23
Mass (Da)
2454
Sequence Removed Signal Peptide
ACGSCRKKCKGSGKCINGRCKCY
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Disulfide Bond
2-15;5-20;9-22
PDB ID
1JLZ
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker Dissociation constant
65 nM
 .
Blocker
 [1]
References
Ref 1 Tc1, from Tityus cambridgei, is the first member of a new subfamily of scorpion toxin that blocks K(+)-channels. FEBS Lett. 2000 Dec 8;486(2):117-20. doi: 10.1016/s0014-5793(00)02253-5.
Ref 2 Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):55-66. doi: 10.1016/j.jchromb.2003.09.002.
Ref 3 Solution structure of a K(+)-channel blocker from the scorpion Tityus cambridgei. Protein Sci. 2002 Feb;11(2):390-400. doi: 10.1110/ps.33402.
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