Peptide Information

General Information of This Peptide
Peptide ID
BTDP008458
Peptide Name
Potassium channel toxin alpha-KTx 12.4
Symonym
Butantoxin
Species
Tityus stigmurus (Brazilian scorpion)
Uniprot Name
KA124_TITST
Alphafold ID
P0C8L1
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C8L1
Sequence
WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
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Sequence Length
40
Mass (Da)
4514
Sequence Removed Signal Peptide
WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
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Disulfide Bond
2-5;10-31;16-36;20-38
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus stigmurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker Dissociation constant
660 nM
 .
Blocker
 [3]
References
Ref 1 NMR solution structure of butantoxin. Arch Biochem Biophys. 2000 Jul 1;379(1):18-27. doi: 10.1006/abbi.2000.1858.
Ref 2 Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jul-Aug;146(1-2):147-157. doi: 10.1016/j.cbpc.2006.12.004. Epub 2006 Dec 16.
Ref 3 Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus. Toxicon. 2003 Feb;41(2):173-9. doi: 10.1016/s0041-0101(02)00247-7.
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