Peptide Information

General Information of This Peptide
Peptide ID
BTDP008417
Peptide Name
Kunitz-type serine protease inhibitor LmKTT-1c
Symonym
Delta-KTx 2.3
Species
Lychas mucronatus (Chinese swimming scorpion)
Uniprot Name
VKT23_LYCMC
Alphafold ID
P0DJ48
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJ48
Sequence
KNKCQLPSDVGKGKASFTRYFYNEESGKCETFIYGGMGGNSNNFLTKEACCRECAQGSC
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Sequence Length
59
Mass (Da)
6459
Sequence Removed Signal Peptide
KNKCQLPSDVGKGKASFTRYFYNEESGKCETFIYGGMGGNSNNFLTKEACCRECAQGSC
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Disulfide Bond
4-54;29-50;51-59
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Lychas
Species: Lychas mucronatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Dissociation constant
124 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
50 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
1 μM
 .
Blocker
 [1]
References
Ref 1 Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem. 2012 Apr 20;287(17):13813-21. doi: 10.1074/jbc.M112.343996. Epub 2012 Feb 21.
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