Peptide Information

General Information of This Peptide
Peptide ID
BTDP008415
Peptide Name
Kunitz-type serine protease inhibitor LmKTT-1a
Symonym
Delta-KTx 2.1; SdPII
Species
Lychas mucronatus (Chinese swimming scorpion)
Uniprot Name
VKT21_LYCMC
Alphafold ID
P0DJ46
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2M01
Sequence
MKSFLLIALVLFFLFVSYASAKKKCQLPSDVGKGKASFTRYYYNEESGKCETFIYGGVGG
NSNNFLTKEDCCRECAQGSC
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Sequence Length
80
Mass (Da)
8864
Signal Sequence
MKSFLLIALVLFFLFVSYASA
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Sequence Removed Signal Peptide
KKKCQLPSDVGKGKASFTRYYYNEESGKCETFIYGGVGGNSNNFLTKEDCCRECAQGSC
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Disulfide Bond
25-75;50-71;72-80
PDB ID
2M01
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Lychas
Species: Lychas mucronatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
140 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1 Inhibition rate
25 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Inhibition rate
25 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 Inhibition rate
50 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 IC50
1 μM
 .
Blocker
 [4]
 Target Info    Kv1.3 IC50
1.58 μM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 2010 Jul 28;11:452. doi: 10.1186/1471-2164-11-452.
Ref 2 Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. PLoS One. 2013;8(4):e60201. doi: 10.1371/journal.pone.0060201. Epub 2013 Apr 3.
Ref 3 SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. PLoS One. 2011;6(11):e27548. doi: 10.1371/journal.pone.0027548. Epub 2011 Nov 8.
Ref 4 Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem. 2012 Apr 20;287(17):13813-21. doi: 10.1074/jbc.M112.343996. Epub 2012 Feb 21.
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