Peptide Information

General Information of This Peptide
Peptide ID
BTDP008404
Peptide Name
Kunitz-type serine protease inhibitor BmKTT-3
Symonym
Delta-KTx 1.2
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
VKT12_MESMA
Alphafold ID
P0DJ47
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJ47
Sequence
KHGSINCRLPPERGPCRGNITKYYYHNESRTCRTFSYGGCEGNSNNFRNRHYCMKYCARK
RHGWLGTGWI
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Sequence Length
70
Mass (Da)
8261
Sequence Removed Signal Peptide
KHGSINCRLPPERGPCRGNITKYYYHNESRTCRTFSYGGCEGNSNNFRNRHYCMKYCARK
RHGWLGTGWI
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Disulfide Bond
7-57;16-40;32-53
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Dissociation constant
760 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
18 %
1 μM
Blocker
 [1]
References
Ref 1 Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem. 2012 Apr 20;287(17):13813-21. doi: 10.1074/jbc.M112.343996. Epub 2012 Feb 21.
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