Peptide Information

General Information of This Peptide
Peptide ID
BTDP008387
Peptide Name
Kappa-scoloptoxin(03)-Ssd1a
Symonym
Toxin SSD609
Species
Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani)
Uniprot Name
TX31A_SCODE
Alphafold ID
A0A0R4I951
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MVT
Sequence
MKFSMAILLVMAPIMFSLDKCYSADDKCEDSLRREIACTKCRDRVRTDDYFYECCTSEST
FKKCQTMLHQ
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Sequence Length
70
Mass (Da)
8253
Signal Sequence
MKFSMAILLVMAPIMFSLDKCYS
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Sequence Removed Signal Peptide
ADDKCEDSLRREIACTKCRDRVRTDDYFYECCTSESTFKKCQTMLHQ
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Disulfide Bond
28-55;38-54;41-64
PDB ID
2MVT
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Chilopoda
Order: Scolopendromorpha
Family: Scolopendridae
Genus: Scolopendra
Species: Scolopendra dehaani
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 Inhibition rate .
1 μM
Modifier
 [1], [2]
 Target Info    KCNQ1 and KCNE3 Inhibition rate
30 %
1 μM
Modifier
 [1], [2]
 Target Info    KCNQ1 and KCNE1 IC50
652 nM
 .
Modifier
 [1], [2]
 Target Info    Kv7.1 IC50
652.7 nM
 .
Modifier
 [1], [2]
References
Ref 1 Venomic and transcriptomic analysis of centipede Scolopendra subspinipes dehaani. J Proteome Res. 2012 Dec 7;11(12):6197-212. doi: 10.1021/pr300881d. Epub 2012 Nov 29.
Ref 2 A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit. Sci Rep. 2015 Aug 26;5:13399. doi: 10.1038/srep13399.
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