Peptide Information

General Information of This Peptide
Peptide ID
BTDP008367
Peptide Name
Cysteine-rich venom protein natrin-1
Symonym
Cysteine-rich venom protein 1; NA-CRVP1; Protein G2a
Species
Naja atra (Chinese cobra)
Uniprot Name
CRVP1_NAJAT
Alphafold ID
Q7T1K6
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1XTA
Sequence
MIAFSLLCFAAVLQQSFGNVDFNSESTRRKKKQKEIVDLHNSLRRRVSPTASNMLKMEWY
PEAASNAERWANTCSLNHSPDNLRVLEGIQCGESIYMSSNARTWTEIIHLWHDEYKNFVY
GVGANPPGSVTGHYTQIVWYQTYRAGCAVSYCPSSAWSYFYVCQYCPSGNFQGKTATPYK
LGPPCGDCPSACDNGLCTNPCTIYNKLTNCDSLLKQSSCQDDWIKSNCPASCFCRNKII
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Sequence Length
239
Mass (Da)
26882
Signal Sequence
MIAFSLLCFAAVLQQSFG
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Sequence Removed Signal Peptide
NVDFNSESTRRKKKQKEIVDLHNSLRRRVSPTASNMLKMEWYPEAASNAERWANTCSLNH
SPDNLRVLEGIQCGESIYMSSNARTWTEIIHLWHDEYKNFVYGVGANPPGSVTGHYTQIV
WYQTYRAGCAVSYCPSSAWSYFYVCQYCPSGNFQGKTATPYKLGPPCGDCPSACDNGLCT
NPCTIYNKLTNCDSLLKQSSCQDDWIKSNCPASCFCRNKII
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Disulfide Bond
74-152;91-166;147-163;185-192;188-197;201-234;210-228;219-232
PDB ID
1XTA , 1XX5 , 2GIZ , 3MZ8
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja atra
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate
46 %
200 nM
Modifier
 [1- 6]
 Target Info    KCa1.1 IC50
34.4 nM
 .
Modifier
 [1- 6]
References
Ref 1 Purification and cloning of cysteine-rich proteins from Trimeresurus jerdonii and Naja atra venoms. Toxicon. 2003 Oct;42(5):539-47. doi: 10.1016/s0041-0101(03)00234-4.
Ref 2 Purification and characterization of Taiwan cobra venom proteins with weak toxicity. Toxicon. 2005 Jan;45(1):21-5. doi: 10.1016/j.toxicon.2004.09.002.
Ref 3 Structural and functional analysis of natrin, a venom protein that targets various ion channels. Biochem Biophys Res Commun. 2006 Dec 15;351(2):443-8. doi: 10.1016/j.bbrc.2006.10.067. Epub 2006 Oct 20.
Ref 4 Structural and functional characterization of ryanodine receptor-natrin toxin interaction. Biophys J. 2008 Nov 1;95(9):4289-99. doi: 10.1529/biophysj.108.137224. Epub 2008 Jul 25.
Ref 5 Purification, crystallization and preliminary X-ray crystallographic analysis of a cysteine-rich secretory protein (CRISP) from Naja atra venom. Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1912-5. doi: 10.1107/S0907444904019766. Epub 2004 Sep 23.
Ref 6 Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel. Biochemistry. 2005 Aug 2;44(30):10145-52. doi: 10.1021/bi050614m.
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