Peptide Information

General Information of This Peptide
Peptide ID
BTDP008343
Peptide Name
Alpha-conotoxin GVIIIB
Symonym
AlphaS-conotoxin GVIIIB
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CSA8A_CONGE
Alphafold ID
X5IWT5
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: X5IWT5
Sequence
MMSKMGAMFVLLLLFTLASSQQEGDVQARKTRPKSDFYRALPRSGSTCTCFTSTNCQGSC
ECLSPPGCYCSNNGIRQPGCSCTCPGTG
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Sequence Length
88
Mass (Da)
9377
Signal Sequence
MMSKMGAMFVLLLLFTLASS
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Sequence Removed Signal Peptide
QQEGDVQARKTRPKSDFYRALPRSGSTCTCFTSTNCQGSCECLSPPGCYCSNNGIRQPGC
SCTCPGTG
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-9-alpha-10 IC50
9.79 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
˜1 μM
 . . [1], [2]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
˜1 μM
 . . [1], [2]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 S-conotoxin GVIIIB potently and selectively blocks 910 nicotinic acetylcholine receptors. Biochem Pharmacol. 2015 Aug 15;96(4):349-56. doi: 10.1016/j.bcp.2015.06.007. Epub 2015 Jun 11.
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