Peptide Information

General Information of This Peptide
Peptide ID
BTDP008341
Peptide Name
Alpha-conotoxin GIB
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CAIB_CONGE
Alphafold ID
X5IGW1
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: X5IGW1
Sequence
MGMRMMFTVFLLVVLATTVVSFPSERASDGRDDTAKDEGSDMEKLVEKKECCNPACGRHY
SCKGGR
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Sequence Length
66
Mass (Da)
7293
Signal Sequence
MGMRMMFTVFLLVVLATTVVS
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Sequence Removed Signal Peptide
FPSERASDGRDDTAKDEGSDMEKLVEKKECCNPACGRHYSCKGGR
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Disulfide Bond
51-56;52-62
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR muscle-type alpha-1-beta-1-delta-epsilon IC50
116 nM
 . . [1], [2]
 Target Info    nAChR muscle-type alpha-1-beta-1-delta-epsilon IC50
643 nM
 . . [1], [2]
 Target Info    nAChR alpha-9-alpha-10 IC50
1.113 μM
 .
By globular isomer
 [1], [2]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 Globular and ribbon isomers of Conus geographus -conotoxins antagonize human nicotinic acetylcholine receptors. Biochem Pharmacol. 2021 Aug;190:114638. doi: 10.1016/j.bcp.2021.114638. Epub 2021 May 29.
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