Peptide Information

General Information of This Peptide
Peptide ID
BTDP008237
Peptide Name
Alpha-conotoxin QcIA
Symonym
A superfamily conotoxin Qc1.11; A superfamily conotoxin Qc1.16; Alpha4/7-conotoxin QuIA
Species
Conus quercinus (Oak cone)
Uniprot Name
CA1A_CONQU
Alphafold ID
S4UJW3
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: S4UJW3
Sequence
MGMRMMFTLFLLAVLSTTVVSFTLDRASNGRDAAADSKAADQIAQTVRDECCSNPSCAQT
HPEICRRTLMLQNPLNHDMSPSA
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Sequence Length
83
Mass (Da)
9062
Signal Sequence
MGMRMMFTLFLLAVLSTTVVS
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Sequence Removed Signal Peptide
FTLDRASNGRDAAADSKAADQIAQTVRDECCSNPSCAQTHPEICRRTLMLQNPLNHDMSP
SA
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Disulfide Bond
51-57;52-65
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus quercinus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
55.7 nM
 . . [1], [2]
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
90.69 nM
 . . [1], [2]
References
Ref 1 High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. Mar Drugs. 2019 Mar 26;17(3):193. doi: 10.3390/md17030193.
Ref 2 A Novel 4/7-Conotoxin QuIA Selectively Inhibits 32 and 6/34 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy. Mar Drugs. 2022 Feb 17;20(2):146. doi: 10.3390/md20020146.
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