Peptide Information

General Information of This Peptide
Peptide ID
BTDP008121
Peptide Name
Delta-conotoxin GmVIA
Species
Conus gloriamaris (Glory-of-the-Sea cone)
Uniprot Name
O16A_CONGL
Alphafold ID
Q9TWM7
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q9TWM7
Sequence
MKLTCMMIVAVLFLTAWTFVTADDSGNGMEILFPKAGHEMENLEVSNRVKPCRKEGQLCD
PIFQNCCRGWNCVLFCV
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Sequence Length
77
Mass (Da)
8705
Signal Sequence
MKLTCMMIVAVLFLTAWTFVTA
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Sequence Removed Signal Peptide
DDSGNGMEILFPKAGHEMENLEVSNRVKPCRKEGQLCDPIFQNCCRGWNCVLFCV
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Disulfide Bond
52-67;59-72;66-76
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus gloriamaris
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 Effective concentration 50
2.5 μM
 . . [1], [2], [3]
 Target Info    Nav1.4 Effective concentration 50
4.8 μM
 . . [1], [2], [3]
References
Ref 1 Delta-conotoxin GmVIA, a novel peptide from the venom of Conus gloriamaris. Biochemistry. 1994 Sep 27;33(38):11420-5. doi: 10.1021/bi00204a003.
Ref 2 Alterations of voltage-activated sodium current by a novel conotoxin from the venom of Conus gloriamaris. J Neurophysiol. 1995 Mar;73(3):1295-301. doi: 10.1152/jn.1995.73.3.1295.
Ref 3 Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci. 2000 Jan 1;20(1):76-80. doi: 10.1523/JNEUROSCI.20-01-00076.2000.
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