Peptide Information

General Information of This Peptide
Peptide ID
BTDP008017
Peptide Name
Neurotoxin BmK-M11
Symonym
Alpha-neurotoxin TX14; BmK M4'; BmK-XI
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
SCXB_MESMA
Alphafold ID
Q9N682
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q9N682
Sequence
MNYLVMISFALLLMTGVESVRDAYIAKPENCVYHCATNEGCNKLCTDNGAESGYCQWGGK
YGNACWCIKLPDDVPIRVPGKCHR
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Sequence Length
84
Mass (Da)
9308
Signal Sequence
MNYLVMISFALLLMTGVES
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Sequence Removed Signal Peptide
VRDAYIAKPENCVYHCATNEGCNKLCTDNGAESGYCQWGGKYGNACWCIKLPDDVPIRVP
GKCHR
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Disulfide Bond
31-82;35-55;41-65;45-67
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Effective concentration 50
82.3 nM
 . . [1], [2], [3]
 Target Info    Nav1.2 Effective concentration 50
>30 μM
 . . [1], [2], [3]
References
Ref 1 Cloning and characterization of the cDNA sequences of two venom peptides from Chinese scorpion Buthus martensii Karsch (BmK). Toxicon. 2000 Jul;38(7):893-9. doi: 10.1016/s0041-0101(99)00192-0.
Ref 2 Nine novel precursors of Buthus martensii scorpion alpha-toxin homologues. Toxicon. 2000 Dec;38(12):1653-61. doi: 10.1016/s0041-0101(00)00081-7.
Ref 3 Recombinant expression, purification, and characterization of scorpion toxin BmTX14. Protein Expr Purif. 2012 Apr;82(2):325-31. doi: 10.1016/j.pep.2012.02.001. Epub 2012 Feb 10.
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