Peptide Information

General Information of This Peptide
Peptide ID
BTDP007767
Peptide Name
Snake venom metalloproteinase atroxase
Symonym
Nonhemorrhagic metalloprotease atroxase
Species
Crotalus atrox (Western diamondback rattlesnake)
Uniprot Name
VM1AT_CROAT
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
EDQQNLSQRYIELVVVADHRVFMKYNSDLNIIRKRVHELVNTINGFYRSLNIDVSLTDLE
IWSDQDFITVDSSAKNTLNSFGEWREADLLRRKSHDHAQLLTAINFEGKIIGRAYTSSMC
NPRKSVGIXKDHSPINLLVGVTMAHELGHNLGMNHDGEKCLRGASLCIMRPGLTPGRSYE
FSDDSMGYYQSFLKQYNPQIXNK
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Sequence Length
203
Mass (Da)
23204
Sequence Removed Signal Peptide
EDQQNLSQRYIELVVVADHRVFMKYNSDLNIIRKRVHELVNTINGFYRSLNIDVSLTDLE
IWSDQDFITVDSSAKNTLNSFGEWREADLLRRKSHDHAQLLTAINFEGKIIGRAYTSSMC
NPRKSVGIXKDHSPINLLVGVTMAHELGHNLGMNHDGEKCLRGASLCIMRPGLTPGRSYE
FSDDSMGYYQSFLKQYNPQIXNK
   Click to Show/Hide
Disulfide Bond
160-167
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Crotalus
Species: Crotalus atrox
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    fibrinogen Inhibition rate
60 %
 .
Decrease in the rat plasma fibrinogen level
 [1], [2], [3], [4]
References
Ref 1 Nucleotide sequence encoding the snake venom fibrinolytic enzyme atroxase obtained from a Crotalus atrox venom gland cDNA library. Arch Biochem Biophys. 1995 Mar 10;317(2):357-64. doi: 10.1006/abbi.1995.1175.
Ref 2 Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches. J Proteome Res. 2009 Jun;8(6):3055-67. doi: 10.1021/pr900249q.
Ref 3 Purification and biochemical characterization of atroxase, a nonhemorrhagic fibrinolytic protease from western diamondback rattlesnake venom. Biochemistry. 1988 Jun 28;27(13):4769-77. doi: 10.1021/bi00413a028.
Ref 4 Thrombolysis with a snake venom protease in a rat model of venous thrombosis. Thromb Res. 1989 Jan 1;53(1):19-29. doi: 10.1016/0049-3848(89)90112-6.
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