Peptide Information

General Information of This Peptide
Peptide ID
BTDP007751
Peptide Name
Kunitz-type serine protease inhibitor textilinin-1
Symonym
Txln-1
Species
Pseudonaja textilis textilis (Eastern brown snake)
Uniprot Name
VKT1_PSETT
Alphafold ID
Q90WA1
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 3BYB
Sequence
MSSGGLLLLLGLLTLWEVLTPVSSKDRPDFCELPADTGPCRVRFPSFYYNPDEKKCLEFI
YGGCEGNANNFITKEECESTCAA
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Sequence Length
83
Mass (Da)
9173
Signal Sequence
MSSGGLLLLLGLLTLWEALTPVSS
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Sequence Removed Signal Peptide
KDRPDFCELPADTGPCRVRFPSFYYNPDEKKCLEFIYGGCEGNANNFITKEECESTCAA
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Disulfide Bond
31-81;40-64;56-77
PDB ID
3BYB , 3D65 , 3UIR , 5ZJ3
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Pseudonaja
Species: Pseudonaja textilis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
0.42 nM
 . . [1- 10]
 Target Info    plasmin Inhibition constant
0.44 nM
 . . [1- 10]
 Target Info    plasma kallikrein Inhibition constant
1.87 μM
 . . [1- 10]
 Target Info    tissue kallikrein Inhibition constant
12.9 μM
 . . [1- 10]
References
Ref 1 A family of textilinin genes, two of which encode proteins with antihaemorrhagic properties. Br J Haematol. 2002 Nov;119(2):376-84. doi: 10.1046/j.1365-2141.2002.03878.x.
Ref 2 Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors that reduce bleeding in an animal model. Blood Coagul Fibrinolysis. 2000 Jun;11(4):385-93. doi: 10.1097/00001721-200006000-00011.
Ref 3 Comparison of textilinin-1 with aprotinin as serine protease inhibitors and as antifibrinolytic agents. Pathophysiol Haemost Thromb. 2005;34(4-5):188-93. doi: 10.1159/000092421.
Ref 4 Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss. Br J Haematol. 2009 Apr;145(2):207-11. doi: 10.1111/j.1365-2141.2009.07605.x. Epub 2009 Feb 22.
Ref 5 Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms. Biochimie. 2012 Feb;94(2):365-73. doi: 10.1016/j.biochi.2011.08.003. Epub 2011 Aug 11.
Ref 6 Drug development from Australian elapid snake venoms and the Venomics pipeline of candidates for haemostasis: Textilinin-1 (Q8008), Haempatch? (Q8009) and CoVase? (V0801). Toxicon. 2012 Mar 15;59(4):456-63. doi: 10.1016/j.toxicon.2010.12.010. Epub 2010 Dec 22.
Ref 7 Molecular diversity in venom from the Australian Brown snake, Pseudonaja textilis. Mol Cell Proteomics. 2006 Feb;5(2):379-89. doi: 10.1074/mcp.M500270-MCP200. Epub 2005 Nov 10.
Ref 8 Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt 7):642-5. doi: 10.1107/S1744309106019099. Epub 2006 Jun 10.
Ref 9 Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS J. 2009 Jun;276(11):3163-75. doi: 10.1111/j.1742-4658.2009.07034.x. Epub 2009 Apr 28.
Ref 10 The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One. 2013;8(1):e54104. doi: 10.1371/journal.pone.0054104. Epub 2013 Jan 15.
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