Peptide Information

General Information of This Peptide
Peptide ID
BTDP007557
Peptide Name
Erabutoxin c
Symonym
Short neurotoxin 1c
Species
Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Uniprot Name
3S1EC_LATSE
Alphafold ID
Q7T2I5
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6PNW
Sequence
MKTLLLTLVVVTIVCLDLGYTRICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIER
GCGCPTVKPGINLSCCESEVCNN
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Sequence Length
83
Mass (Da)
9146
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
RICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIERGCGCPTVKPGINLSCCESEVC
NN
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Disulfide Bond
24-45;38-62;64-75;76-81
PDB ID
6PNW
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Laticauda
Species: Laticauda semifasciata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Dissociation constant
0.14 nM
 . . [1- 5]
References
Ref 1 Structure of the snake short-chain neurotoxin, erabutoxin c, precursor gene. Eur J Biochem. 1990 Nov 13;193(3):629-33. doi: 10.1111/j.1432-1033.1990.tb19380.x.
Ref 2 Molecular evolution and diversification of snake toxin genes, revealed by analysis of intron sequences. Gene. 2003 Aug 14;313:111-8. doi: 10.1016/s0378-1119(03)00637-1.
Ref 3 The isolation, properties and amino acid sequence of erabutoxin c, a minor neurotoxic component of the venom of a sea snake Katicauda semifasciata. Biochem J. 1972 Nov;130(2):547-55. doi: 10.1042/bj1300547.
Ref 4 Correction of partial amino acid sequence of erabutoxins. Biochem J. 1977 Oct 1;167(1):289-91. doi: 10.1042/bj1670289.
Ref 5 Genetic engineering of snake toxins. The functional site of Erabutoxin a, as delineated by site-directed mutagenesis, includes variant residues. J Biol Chem. 1995 Apr 21;270(16):9362-9. doi: 10.1074/jbc.270.16.9362.
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