Peptide Information

General Information of This Peptide
Peptide ID
BTDP007426
Peptide Name
Alpha-conotoxin-like Qc1.2
Symonym
Qu-3
Species
Conus quercinus (Oak cone)
Uniprot Name
CA12_CONQU
Alphafold ID
Q6PTD6
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q6PTD6
Sequence
MGMRMMFTVFLLVALATTVASFTLDRASNGRNAAADDKPSDWIALAIKQCCANPPCKHVN
CR
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Sequence Length
62
Mass (Da)
6745
Signal Sequence
MGMRMMFTVFLLVALATTVAS
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Sequence Removed Signal Peptide
FTLDRASNGRNAAADDKPSDWIALAIKQCCANPPCKHVNCR
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Disulfide Bond
50-56;51-61
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus quercinus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-4 Inhibition rate
37 %
10 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-3-beta-2 Inhibition rate
63 %
10 μM
 . [1], [2], [3]
References
Ref 1 From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon. 2007 Jun 15;49(8):1135-49. doi: 10.1016/j.toxicon.2007.02.011. Epub 2007 Mar 1.
Ref 2 High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. Mar Drugs. 2019 Mar 26;17(3):193. doi: 10.3390/md17030193.
Ref 3 Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim Biophys Sin (Shanghai). 2009 Oct;41(10):858-64. doi: 10.1093/abbs/gmp077.
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