Peptide Information

General Information of This Peptide
Peptide ID
BTDP007321
Peptide Name
U3-agatoxin-Ao1f
Symonym
Beta/delta-agatoxin-1; Mu-2Aga_07
Species
Agelena orientalis (Funnel-web spider)
Uniprot Name
T4G1F_AGEOR
Alphafold ID
Q5Y4V3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: Q5Y4V3
Sequence
MRAIISLLLISTMVFGVIEAVSLEEGLKIFEGERGDCVGESQQCADWSGPYCCKGYYCTC
RYFPKCICVNDNGK
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Sequence Length
74
Mass (Da)
8214
Signal Sequence
MRAIISLLLISTMVFGVIEA
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Sequence Removed Signal Peptide
VSLEEGLKIFEGERGDCVGESQQCADWSGPYCCKGYYCTCRYFPKCICVNDNGK
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Disulfide Bond
37-53;44-58;52-68;60-66
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Agelenidae
Genus: Agelena
Species: Agelena orientalis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 Inhibition rate .
1 μM
 . [1], [2]
References
Ref 1 A novel strategy for the identification of toxinlike structures in spider venom. Proteins. 2005 Apr 1;59(1):131-40. doi: 10.1002/prot.20390.
Ref 2 Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis. J Biol Chem. 2010 Jun 11;285(24):18545-54. doi: 10.1074/jbc.M110.125211. Epub 2010 Apr 12.
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