Peptide Information

General Information of This Peptide
Peptide ID
BTDP007304
Peptide Name
Lufaxin
Symonym
32.4 kDa salivary protein; Lutzomyia longipalpis FXa inhibitor
Species
Lutzomyia longipalpis (Sand fly)
Uniprot Name
LUFX_LUTLO
Alphafold ID
Q5WPU8
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q5WPU8
Sequence
MNSINFLSIVGLISFGFIVAVKCDGDEYFIGKYKEKDETLFFASYGLKRDPCQIVLGYKC
SNNQTHFVLNFKTNKKSCISAIKLTSYPKINQNSDLTKNLYCQTGGIGTDNCKLVFKKRK
RQIAANIEIYGIPAKKCSFKDRYIGADPLHVDSYGLPYQFDQEHGWNVERYNIFKDTRFS
TEVFYHKNGLFNTQITYLAEEDSFSEAREITAKDIKKKFSIILPNEEYKRISFLDVYWFQ
ETMRKKPKYPYIHYNGECSNENKTCELVFDTDELMTYALVKVFTNPESDGSRLKEEDLGR
G
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Sequence Length
301
Mass (Da)
34951
Sequence Removed Signal Peptide
MNSINFLSIVGLISFGFIVAVKCDGDEYFIGKYKEKDETLFFASYGLKRDPCQIVLGYKC
SNNQTHFVLNFKTNKKSCISAIKLTSYPKINQNSDLTKNLYCQTGGIGTDNCKLVFKKRK
RQIAANIEIYGIPAKKCSFKDRYIGADPLHVDSYGLPYQFDQEHGWNVERYNIFKDTRFS
TEVFYHKNGLFNTQITYLAEEDSFSEAREITAKDIKKKFSIILPNEEYKRISFLDVYWFQ
ETMRKKPKYPYIHYNGECSNENKTCELVFDTDELMTYALVKVFTNPESDGSRLKEEDLGR
G
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Psychodidae
Genus: Lutzomyia
Species: Lutzomyia longipalpis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    factor Xa (F10) Dissociation constant
3.86 nM
 . . [1], [2], [3]
References
Ref 1 Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi. J Exp Biol. 2004 Oct;207(Pt 21):3717-29. doi: 10.1242/jeb.01185.
Ref 2 Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2185-98. doi: 10.1161/ATVBAHA.112.253906. Epub 2012 Jul 12.
Ref 3 The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B. Front Immunol. 2017 Aug 31;8:1065. doi: 10.3389/fimmu.2017.01065. eCollection 2017.
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