Peptide Information

General Information of This Peptide
Peptide ID
BTDP007029
Peptide Name
Alpha-conotoxin Lt1a
Symonym
Alpha-conotoxin Lt1.1
Species
Conus litteratus (Lettered cone)
Uniprot Name
CA11_CONLT
Alphafold ID
Q2I2R8
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q2I2R8
Sequence
MGMRMMFIMFMLVVLATTVVTFTSDRALDAMNAAASNKASRLIALAVRGCCARAACAGIH
QELCGGGR
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Sequence Length
68
Mass (Da)
7155
Signal Sequence
MGMRMMFIMFMLVVLATTVVTFTS
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Sequence Removed Signal Peptide
DRALDAMNAAASNKASRLIALAVRGCCARAACAGIHQELCGGGR
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Disulfide Bond
50-56;51-64
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus litteratus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
9.8 - 22.95 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
84.4 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
˜6 μM
 . . [1], [2], [3]
References
Ref 1 Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics. 2006 Dec;88(6):809-819. doi: 10.1016/j.ygeno.2006.06.014. Epub 2006 Aug 14.
Ref 2 Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J Biol Chem. 2010 Apr 16;285(16):12355-66. doi: 10.1074/jbc.M109.079012. Epub 2010 Feb 9.
Ref 3 Design, Synthesis, and Activity of an -Conotoxin LtIA Fluorescent Analogue. ACS Chem Neurosci. 2021 Oct 6;12(19):3662-3671. doi: 10.1021/acschemneuro.1c00392. Epub 2021 Sep 15.
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