General Information of This Peptide
Peptide ID
BTDP006718
Peptide Name
Bradykinin-potentiating peptide 7a
Symonym
Proline-rich peptide 7a
Species
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Uniprot Name
BPP7A_BOTJA
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
QDGPIPP
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Sequence Length
7
Mass (Da)
723
Sequence Removed Signal Peptide
QDGPIPP
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Bothrops
Species: Bothrops jararaca
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    muscarinic acetylcholine receptor M1 Effective concentration 50
0.25 - 0.31 μM
. . [1], [2], [3]
References
Ref 1 Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography. Peptides. 2004 Jul;25(7):1085-92. doi: 10.1016/j.peptides.2004.04.006.
Ref 2 Do the cardiovascular effects of angiotensin-converting enzyme (ACE) I involve ACE-independent mechanisms? new insights from proline-rich peptides of Bothrops jararaca. J Pharmacol Exp Ther. 2007 Aug;322(2):795-805. doi: 10.1124/jpet.107.120873. Epub 2007 May 2.
Ref 3 The snake venom peptide Bj-PRO-7a is a M1 muscarinic acetylcholine receptor agonist. Cytometry A. 2011 Jan;79(1):77-83. doi: 10.1002/cyto.a.20963.
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