Peptide Information

General Information of This Peptide
Peptide ID
BTDP006649
Peptide Name
Conotoxin flf14c
Symonym
Conotoxin flf14.1
Species
Conus anabathrum floridanus (Florida cone) (Conus floridanus floridensis)
Uniprot Name
CREC_CONAW
Alphafold ID
P84707
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P84707
Sequence
MGFRVLVLIVMVTTSALPFTFSEESGRSPFRPALRSEEAQALRHGLTLLLARRADGQTPD
MHQPEMRRPEMRRPEVRRPEVRQPEFAESPVGQKRWDAYDCIQFCMRPEMRHTYAQCLSI
CT
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Sequence Length
122
Mass (Da)
14192
Signal Sequence
MGFRVLVLIVMVTTSALP
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Sequence Removed Signal Peptide
FTFSEESGRSPFRPALRSEEAQALRHGLTLLLARRADGQTPDMHQPEMRRPEMRRPEVRR
PEVRQPEFAESPVGQKRWDAYDCIQFCMRPEMRHTYAQCLSICT
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Disulfide Bond
101-121;105-117
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus anabathrum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate .
10 μM
 . [1], [2]
References
Ref 1 Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds. Peptides. 2018 Sep;107:75-82. doi: 10.1016/j.peptides.2018.06.002. Epub 2018 Jul 21.
Ref 2 A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold. Biochemistry. 2005 Dec 13;44(49):15986-96. doi: 10.1021/bi0511181.
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