Peptide Information

General Information of This Peptide
Peptide ID
BTDP006549
Peptide Name
Mu-hexatoxin-Mg2a
Symonym
Neurotoxin magi-3
Species
Macrothele gigas (Japanese funnel web spider)
Uniprot Name
TX22A_MACGS
Alphafold ID
P83559
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6AX2
Sequence
GGCIKWNHSCQTTTLKCCGKCVVCYCHTPWGTNCRCDRTRLFCTED
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Sequence Length
46
Mass (Da)
5233
Sequence Removed Signal Peptide
GGCIKWNHSCQTTTLKCCGKCVVCYCHTPWGTNCRCDRTRLFCTED
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Disulfide Bond
3-18;10-24;17-36;21-43;26-34
PDB ID
6AX2
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Macrothelidae
Genus: Macrothele
Species: Macrothele gigas
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Inhibition rate
23 %
50 μM
 . [1], [2]
 Target Info    Nav1.4 Inhibition rate
35 %
100 μM
 . [1], [2]
References
Ref 1 Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel. FEBS Lett. 2003 Jul 17;547(1-3):43-50. doi: 10.1016/s0014-5793(03)00666-5.
Ref 2 Successful refolding and NMR structure of rMagi3: A disulfide-rich insecticidal spider toxin. Protein Sci. 2018 Mar;27(3):692-701. doi: 10.1002/pro.3363. Epub 2018 Jan 3.
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