Peptide Information

General Information of This Peptide
Peptide ID
BTDP006486
Peptide Name
Tryptophan-containing weak neurotoxin
Symonym
WTX
Species
Naja kaouthia (Monocled cobra) (Naja siamensis)
Uniprot Name
3NO2_NAJKA
Alphafold ID
P82935
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MJ0
Sequence
MKTLLLTLVVVTIVCLDLGYTLTCLNCPEMFCGKFQICRNGEKICFKKLHQRRPLSWRYI
RGCADTCPVGKPYEMIECCSTDKCNR
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Sequence Length
86
Mass (Da)
9915
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
LTCLNCPEMFCGKFQICRNGEKICFKKLHQRRPLSWRYIRGCADTCPVGKPYEMIECCST
DKCNR
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Disulfide Bond
24-45;27-32;38-63;67-78;79-84
PDB ID
2MJ0
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja kaouthia
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-3-gamma-2 Inhibition rate
31 %
10 μM
 . [1- 10]
References
Ref 1 Direct cloning of a target gene from a pool of homologous sequences: complete cDNA sequence of a weak neurotoxin from cobra Naja kaouthia. IUBMB Life. 2003 Jan;55(1):43-7. doi: 10.1080/1521654021000061664.
Ref 2 First tryptophan-containing weak neurotoxin from cobra venom. Toxicon. 2001 Jul;39(7):921-7. doi: 10.1016/s0041-0101(00)00223-3.
Ref 3 [New weak toxins from the cobra venom]. Bioorg Khim. 2009 Jan-Feb;35(1):15-24. doi: 10.1134/s1068162009010026.
Ref 4 Weak toxin from Naja kaouthia is a nontoxic antagonist of alpha 7 and muscle-type nicotinic acetylcholine receptors. J Biol Chem. 2001 May 11;276(19):15810-5. doi: 10.1074/jbc.M100788200. Epub 2001 Feb 15.
Ref 5 Weak neurotoxin from Naja kaouthia cobra venom affects haemodynamic regulation by acting on acetylcholine receptors. Toxicon. 2005 Jan;45(1):93-9. doi: 10.1016/j.toxicon.2004.09.014.
Ref 6 Behavioural effects in mice and intoxication symptomatology of weak neurotoxin from cobra Naja kaouthia. Basic Clin Pharmacol Toxicol. 2007 Apr;100(4):273-8. doi: 10.1111/j.1742-7843.2007.00045.x.
Ref 7 Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors. FEBS J. 2009 Sep;276(18):5065-75. doi: 10.1111/j.1742-4658.2009.07203.x. Epub 2009 Aug 4.
Ref 8 Neurotoxins from snake venoms and -conotoxin ImI inhibit functionally active ionotropic -aminobutyric acid (GABA) receptors. J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.
Ref 9 Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors. Toxicon. 2016 Sep 1;119:274-9. doi: 10.1016/j.toxicon.2016.06.012. Epub 2016 Jun 23.
Ref 10 Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors. J Biol Chem. 2015 Sep 25;290(39):23616-30. doi: 10.1074/jbc.M115.656595. Epub 2015 Aug 4.
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