Peptide Information

General Information of This Peptide
Peptide ID
BTDP006321
Peptide Name
Alpha-conotoxin OIVA
Symonym
Alpha-A-O4a; Alpha-A-OIVA
Species
Conus obscurus (Obscure cone) (Conus halitropus)
Uniprot Name
CA4A_CONOB
Alphafold ID
P69746
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P69746
Sequence
CCGVPNAACHPCVCKNTC
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Sequence Length
18
Mass (Da)
1823
Sequence Removed Signal Peptide
CCGVPNAACHPCVCKNTC
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Disulfide Bond
1-9;2-14;12-18
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
0.51 nM
 .
Fetal muscle subtype
 [1], [2]
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
310 nM
 .
Adult subtype
 [1], [2]
References
Ref 1 AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon. 2004 Aug;44(2):207-14. doi: 10.1016/j.toxicon.2004.05.026.
Ref 2 Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor. Biochemistry. 2006 Jan 31;45(4):1304-12. doi: 10.1021/bi052016d.
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