Peptide Information

General Information of This Peptide
Peptide ID
BTDP006290
Peptide Name
Omega-theraphotoxin-Hs1a
Symonym
Huwentoxin-10; Huwentoxin-X
Species
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Uniprot Name
TXH10_CYRSC
Alphafold ID
P68424
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1Y29
Sequence
MNMKILVLVAVLCLVVSTHAERHSKTDMEDMEDSPMIQERKCLPPGKPCYGATQKIPCCG
VCSHNKCT
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Sequence Length
68
Mass (Da)
7521
Signal Sequence
MNMKILVLVAVLCLVVSTHA
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Sequence Removed Signal Peptide
ERHSKTDMEDMEDSPMIQERKCLPPGKPCYGATQKIPCCGVCSHNKCT
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Disulfide Bond
42-59;49-62;58-67
PDB ID
1Y29
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schmidti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.2 IC50
40 nM
 . . [1], [2]
References
Ref 1 Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena. J Biol Chem. 2006 Mar 31;281(13):8628-35. doi: 10.1074/jbc.M513542200. Epub 2006 Jan 26.
Ref 2 Molecular diversification based on analysis of expressed sequence tags from the venom glands of the Chinese bird spider Ornithoctonus huwena. Toxicon. 2008 Jun 15;51(8):1479-89. doi: 10.1016/j.toxicon.2008.03.024. Epub 2008 Mar 27.
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