Peptide Information

General Information of This Peptide
Peptide ID
BTDP006258
Peptide Name
Phospholipase A2 crotoxin basic subunit CBc
Symonym
Phosphatidylcholine 2-acylhydrolase
Species
Crotalus durissus terrificus (South American rattlesnake)
Uniprot Name
PA2BC_CRODU
Alphafold ID
P62022
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2QOG
Sequence
MRALWIVAVLLVGVEGHLLQFNKMIKFETRKNAIPFYAFYGCYCGWGGRGRPKDATDRCC
FVHDCCYGKLAKCNTKWDIYPYSLKSGYITCGKGTWCEEQICECDRVAAECLRRSLSTYK
YGYMFYPDSRCRGPSETC
   Click to Show/Hide
Sequence Length
138
Mass (Da)
15907
Signal Sequence
MRALWIVAVLLVGVEG
   Click to Show/Hide
Sequence Removed Signal Peptide
HLLQFNKMIKFETRKNAIPFYAFYGCYCGWGGRGRPKDATDRCCFVHDCCYGKLAKCNTK
WDIYPYSLKSGYITCGKGTWCEEQICECDRVAAECLRRSLSTYKYGYMFYPDSRCRGPSE
TC
   Click to Show/Hide
Disulfide Bond
42-131;44-60;59-111;65-138;66-104;73-97;91-102
PDB ID
2QOG
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Crotalus
Species: Crotalus durissus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    factor Xa (F10) IC50
0.7 nM
 . . [1- 13]
References
Ref 1 Cloning and sequencing of cDNAs encoding the two subunits of Crotoxin. Nucleic Acids Res. 1988 Sep 26;16(18):9050. doi: 10.1093/nar/16.18.9050.
Ref 2 The origin of the diversity of crotoxin isoforms in the venom of Crotalus durissus terrificus. Eur J Biochem. 1994 Jul 1;223(1):161-4. doi: 10.1111/j.1432-1033.1994.tb18978.x.
Ref 3 Molecular evolution and structure-function relationships of crotoxin-like and asparagine-6-containing phospholipases A2 in pit viper venoms. Biochem J. 2004 Jul 1;381(Pt 1):25-34. doi: 10.1042/BJ20040125.
Ref 4 Comparison of crotoxin isoforms reveals that stability of the complex plays a major role in its pharmacological action. Eur J Biochem. 1993 Jun 1;214(2):491-6. doi: 10.1111/j.1432-1033.1993.tb17946.x.
Ref 5 Regulation of epidermal growth factor receptor activity by crotoxin, a snake venom phospholipase A2 toxin. A novel growth inhibitory mechanism. Biochem Pharmacol. 1996 Jun 14;51(11):1535-43. doi: 10.1016/0006-2952(96)00097-4.
Ref 6 Interaction of the neurotoxic and nontoxic secretory phospholipases A2 with the crotoxin inhibitor from Crotalus serum. Eur J Biochem. 2000 Aug;267(15):4799-808. doi: 10.1046/j.1432-1327.2000.01532.x.
Ref 7 Phase I and pharmacokinetics study of crotoxin (cytotoxic PLA(2), NSC-624244) in patients with advanced cancer. Clin Cancer Res. 2002 Apr;8(4):1033-41.
Ref 8 Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics. BMC Struct Biol. 2007 Dec 6;7:82. doi: 10.1186/1472-6807-7-82.
Ref 9 Crotoxin: novel activities for a classic beta-neurotoxin. Toxicon. 2010 Jun 1;55(6):1045-60. doi: 10.1016/j.toxicon.2010.01.011. Epub 2010 Jan 28.
Ref 10 Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric -neurotoxin. J Mol Biol. 2011 Sep 16;412(2):176-91. doi: 10.1016/j.jmb.2011.07.027. Epub 2011 Jul 23.
Ref 11 Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ?F508CFTR Dysfunction: Impact in Cystic Fibrosis. J Mol Biol. 2016 Jul 17;428(14):2898-915. doi: 10.1016/j.jmb.2016.05.016. Epub 2016 May 27.
Ref 12 Crotoxin promotes macrophage reprogramming towards an antiangiogenic phenotype. Sci Rep. 2019 Mar 12;9(1):4281. doi: 10.1038/s41598-019-40903-0.
Ref 13 Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom. Proteins. 2008 Aug 15;72(3):883-91. doi: 10.1002/prot.21980.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.