Peptide Information

General Information of This Peptide
Peptide ID
BTDP006205
Peptide Name
Alpha-conotoxin GID
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CA1D_CONGE
Alphafold ID
P60274
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1MTQ
Sequence
MGMRMMFTVFLLVVLAATIVSFTSDRASDGRNVAAKAFHRIGRTIRDECCSNPACRVNNP
HVCRRR
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Sequence Length
66
Mass (Da)
7428
Signal Sequence
MGMRMMFTVFLLVVLAATIVS
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Sequence Removed Signal Peptide
FTSDRASDGRNVAAKAFHRIGRTIRDECCSNPACRVNNPHVCRRR
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Disulfide Bond
49-55;50-63
PDB ID
1MTQ , 5UG3 , 5UG5
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
3.1 - 5.1 nM
 . . [1- 6]
 Target Info    nAChR alpha-7 IC50
4.5 - 5.1 nM
 . . [1- 6]
 Target Info    nAChR alpha-4-beta-2 IC50
128.6 - 390 nM
 . . [1- 6]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem. 2003 Jan 31;278(5):3137-44. doi: 10.1074/jbc.M210280200. Epub 2002 Nov 4.
Ref 3 Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. J Biol Chem. 2005 Aug 26;280(34):30460-8. doi: 10.1074/jbc.M504229200. Epub 2005 Jun 1.
Ref 4 Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. 2009 Feb 20;284(8):4944-51. doi: 10.1074/jbc.M804950200. Epub 2008 Dec 19.
Ref 5 Design and synthesis of -conotoxin GID analogues as selective 42 nicotinic acetylcholine receptor antagonists. Biopolymers. 2014 Jan;102(1):78-87. doi: 10.1002/bip.22413.
Ref 6 Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8100-E8109. doi: 10.1073/pnas.1703952114. Epub 2017 Sep 5.
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