Peptide Information

General Information of This Peptide
Peptide ID
BTDP006175
Peptide Name
Mu-conotoxin SmIIIA
Species
Conus stercusmuscarum (Fly-specked cone)
Uniprot Name
CM3A_CONSE
Alphafold ID
P60207
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1Q2J
Sequence
PLFDKRQRCCNGRRGCSSRWCRDHSRCCGRR
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Sequence Length
31
Mass (Da)
3756
Sequence Removed Signal Peptide
PLFDKRQRCCNGRRGCSSRWCRDHSRCCGRR
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Disulfide Bond
9-21;10-27;16-28
PDB ID
1Q2J
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus stercusmuscarum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Dissociation constant
0.22 nM
 . . [1- 5]
 Target Info    Nav1.2 Dissociation constant
1.3 nM
 . . [1- 5]
 Target Info    Nav1.1 Dissociation constant
3.8 nM
 . . [1- 5]
 Target Info    Nav1.6 Dissociation constant
69 nM
 . . [1- 5]
 Target Info    Nav1.7 Dissociation constant
260 nM
 . . [1- 5]
 Target Info    Nav1.6 IC50
160 nM
 . . [1- 5]
 Target Info    Nav1.8 IC50
>10 μM
 . . [1- 5]
 Target Info    Nav1.7 IC50
1.3 μM
 . . [1- 5]
 Target Info    Nav1.5 IC50
1.3 μM
 . . [1- 5]
References
Ref 1 Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons. Biochemistry. 2002 Dec 24;41(51):15388-93. doi: 10.1021/bi0265628.
Ref 2 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 3 A novel -conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Br J Pharmacol. 2012 Jul;166(5):1654-68. doi: 10.1111/j.1476-5381.2012.01837.x.
Ref 4 Co-expression of Na(V) subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking -conotoxins. Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051.
Ref 5 Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA. J Biol Chem. 2003 Nov 21;278(47):46805-13. doi: 10.1074/jbc.M309222200. Epub 2003 Sep 10.
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