Peptide Information

General Information of This Peptide
Peptide ID
BTDP006049
Peptide Name
Mu-conotoxin MrVIA
Symonym
Conotoxin Mr6.5
Species
Conus marmoreus (Marble cone)
Uniprot Name
O16A_CONMR
Alphafold ID
P56708
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P56708
Sequence
MKLTCMMIVAVLFLTAWTLVMADDSNNGLANHFSKSRDEMEDPEASKLEKRACRKKWEYC
IVPIIGFIYCCPGLICGPFVCV
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Sequence Length
82
Mass (Da)
9267
Signal Sequence
MKLTCMMIVAVLFLTAWTLVMA
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Sequence Removed Signal Peptide
DDSNNGLANHFSKSRDEMEDPEASKLEKRACRKKWEYCIVPIIGFIYCCPGLICGPFVCV
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Disulfide Bond
53-71;60-76;70-81
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus marmoreus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
345 nM
 . . [1- 6]
 Target Info    Nav1.4 IC50
438 nM
 . . [1- 6]
 Target Info    Nav1.2 IC50
532 nM
 . . [1- 6]
References
Ref 1 Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon. 2012 Nov;60(6):982-9. doi: 10.1016/j.toxicon.2012.06.011. Epub 2012 Jul 7.
Ref 2 New sodium channel-blocking conotoxins also affect calcium currents in Lymnaea neurons. Biochemistry. 1995 Apr 25;34(16):5364-71. doi: 10.1021/bi00016a007.
Ref 3 A new family of conotoxins that blocks voltage-gated sodium channels. J Biol Chem. 1995 Jul 14;270(28):16796-802. doi: 10.1074/jbc.270.28.16796.
Ref 4 MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I. J Neurophysiol. 1996 Sep;76(3):1423-9. doi: 10.1152/jn.1996.76.3.1423.
Ref 5 Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci. 2000 Jan 1;20(1):76-80. doi: 10.1523/JNEUROSCI.20-01-00076.2000.
Ref 6 The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3. FEBS Lett. 2006 Feb 20;580(5):1360-4. doi: 10.1016/j.febslet.2006.01.057. Epub 2006 Jan 26.
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